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Page 1
Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers.
Bledea R, Vasudevaraja V, Patel S, Stafford J, Serrano J, Esposito G, Tredwin LM, Goodman N, Kloetgen A, Golfinos JG, Zagzag D, Weigelt B, Iafrate AJ, Sulman EP, Chi AS, Dogan S, Reis-Filho JS, Chiang S, Placantonakis D, Tsirigos A, Snuderl M. Bledea R, et al. Sci Rep. 2019 Nov 14;9(1):16830. doi: 10.1038/s41598-019-53262-7. Sci Rep. 2019. PMID: 31727977 Free PMC article.
IDH1/2 mutations are early drivers present in diverse human cancer types arising in various tissue sites. IDH1/2 mutation is known to induce a global hypermethylator phenotype. ...
IDH1/2 mutations are early drivers present in diverse human cancer types arising in various tissue sites. IDH1/2 mutati …
Clinical, histological, and molecular features of gliomas in adults with neurofibromatosis type 1.
Romo CG, Piotrowski AF, Campian JL, Diarte J, Rodriguez FJ, Bale TA, Dahiya S, Gutmann DH, Lucas CG, Prichett L, Mellinghoff I, Blakeley JO. Romo CG, et al. Neuro Oncol. 2023 Aug 3;25(8):1474-1486. doi: 10.1093/neuonc/noad033. Neuro Oncol. 2023. PMID: 36840626 Free PMC article.
RESULTS: Forty-five patients, comprising 23 females (51%), met eligibility criteria, with a median of age 37 (18-68 years) and performance status of 80% (30%-100%). Tissue was available for 35 patients. Diagnoses included infiltrating (low-grade) astrocytoma (9), glioblast …
RESULTS: Forty-five patients, comprising 23 females (51%), met eligibility criteria, with a median of age 37 (18-68 years) and performance s …
The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases.
Solary E, Bernard OA, Tefferi A, Fuks F, Vainchenker W. Solary E, et al. Leukemia. 2014 Mar;28(3):485-96. doi: 10.1038/leu.2013.337. Epub 2013 Nov 13. Leukemia. 2014. PMID: 24220273 Review.
Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation, deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event in myeloid and lymphoid malignancies. ...TET dioxygenases require 2-oxoglutarate, oxygen and Fe(II) for …
Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation, deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and …
Maffucci syndrome and neoplasms: a case report and review of the literature.
Prokopchuk O, Andres S, Becker K, Holzapfel K, Hartmann D, Friess H. Prokopchuk O, et al. BMC Res Notes. 2016 Feb 27;9:126. doi: 10.1186/s13104-016-1913-x. BMC Res Notes. 2016. PMID: 26920730 Free PMC article. Review.
IHCC) and also with Maffucci syndrome. For IHCC, mutations in IDH1/IDH2 are associated with higher survival rates. IHCC tissue as well as normal liver tissue and peripheral blood were analyzed for IDH1/IDH2-mutations in our patient. In the tumor sample …
IHCC) and also with Maffucci syndrome. For IHCC, mutations in IDH1/IDH2 are associated with higher survival rates. IHCC tissue …
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW. Sasaki M, et al. Genes Dev. 2012 Sep 15;26(18):2038-49. doi: 10.1101/gad.198200.112. Epub 2012 Aug 27. Genes Dev. 2012. PMID: 22925884 Free PMC article.
Isocitrate dehydrogenase-1 (IDH1) R132 mutations occur in glioma, but their physiological significance is unknown. Here we describe the generation and characterization of brain-specific Idh1 R132H conditional knock-in (KI) mice. Idh1 mutation results in hemor …
Isocitrate dehydrogenase-1 (IDH1) R132 mutations occur in glioma, but their physiological significance is unknown. Here we describe t …
Tumor-Derived Pericytes Driven by EGFR Mutations Govern the Vascular and Immune Microenvironment of Gliomas.
Segura-Collar B, Garranzo-Asensio M, Herranz B, Hernández-SanMiguel E, Cejalvo T, Casas BS, Matheu A, Pérez-Núñez Á, Sepúlveda-Sánchez JM, Hernández-Laín A, Palma V, Gargini R, Sánchez-Gómez P. Segura-Collar B, et al. Cancer Res. 2021 Apr 15;81(8):2142-2156. doi: 10.1158/0008-5472.CAN-20-3558. Epub 2021 Feb 16. Cancer Res. 2021. PMID: 33593822 Free article.
IDH1 regulates phospholipid metabolism in developing astrocytes.
Bogdanovic E, Sadri AR, Catapano M, Vance JE, Jeschke MG. Bogdanovic E, et al. Neurosci Lett. 2014 Oct 17;582:87-92. doi: 10.1016/j.neulet.2014.09.015. Epub 2014 Sep 16. Neurosci Lett. 2014. PMID: 25218477 Free PMC article.
IDH1 has previously been shown to participate in lipid biosynthesis in various tissues such as the liver and adipose tissue. We examined the potential role of IDH1 in phospholipid metabolism in the brain. Here we show that IDH1 is highly express …
IDH1 has previously been shown to participate in lipid biosynthesis in various tissues such as the liver and adipose tissue …
Isocitrate dehydrogenase1 mutation reduces the pericyte coverage of microvessels in astrocytic tumours.
Sun C, Zhao Y, Shi J, Zhang J, Yuan Y, Gu Y, Zhang F, Gao X, Wang C, Wang Y, Wang Z, Hu P, Qin J, Xiao L, Chang T, Wang L, Xi Y, Yin H, Chen H, Zhang L, Cheng G, Lin J, Zhang M, Li Z, Ye J. Sun C, et al. J Neurooncol. 2019 Jun;143(2):187-196. doi: 10.1007/s11060-019-03156-5. Epub 2019 Apr 19. J Neurooncol. 2019. PMID: 31004262
The densities of microvessels in IDH-mutated and wildtype astrocytoma and glioblastoma were assessed by immunohistochemical (IHC) staining with CD34, and the pericytes were labelled with alpha-smooth muscle antigen (alpha-SMA), neural-glial antigen 2 (NG2) and PDGF receptor-beta …
The densities of microvessels in IDH-mutated and wildtype astrocytoma and glioblastoma were assessed by immunohistochemical (IHC) staining w …
Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis.
Liu X, Yamaguchi K, Takane K, Zhu C, Hirata M, Hikiba Y, Maeda S, Furukawa Y, Ikenoue T. Liu X, et al. PLoS One. 2021 Sep 13;16(9):e0257090. doi: 10.1371/journal.pone.0257090. eCollection 2021. PLoS One. 2021. PMID: 34516556 Free PMC article.
To elucidate molecular mechanism(s) associated with IDH1/2 mutations, we established mouse embryonic fibroblasts (MEF) cells and human colorectal cancer cells stably expressing cancer-associated IDH1R132C or IDH2R172S, and analyzed the change in metabolic characteri …
To elucidate molecular mechanism(s) associated with IDH1/2 mutations, we established mouse embryonic fibroblasts (MEF) cells a …
Atypical cartilage in type II germ cell tumors of the mediastinum show significantly different patterns of IDH1/2 mutations from conventional chondrosarcoma.
Warmke LM, Cheng L, Sperling RM, Sen JD, Ulbright TM. Warmke LM, et al. Mod Pathol. 2022 Nov;35(11):1636-1643. doi: 10.1038/s41379-022-01106-7. Epub 2022 Jun 3. Mod Pathol. 2022. PMID: 35660795 Free article.
To better understand the relationship between these tumors and their bone/soft tissue counterpart, we studied the IDH1/2 mutational status of 20 cases of primary mediastinal mixed germ cell tumors with areas of readily identifiable cartilaginous differentiation. Our …
To better understand the relationship between these tumors and their bone/soft tissue counterpart, we studied the IDH1/2 mutat …
20 results